A: When you have high cholesterol, a thick, waxy plaque can build up in your artery walls. As plaque builds up, the artery narrows and becomes less flexible, reducing blood flow. If a blood clot then forms and clogs the artery, you could have a heart attack or stroke.
Your overall cholesterol is important. But guidelines suggest that you focus on your LDL ("bad" cholesterol) level to manage high cholesterol.
Having high "bad" cholesterol means you have too much LDL cholesterol in your blood. LDL is low-density lipoprotein, or "bad" cholesterol. LDL cholesterol can build up in your arteries and prevent the blood from getting to your heart. HDL cholesterol is the "good" cholesterol. It carries LDL cholesterol away from your artery walls.